SMARTER

Development of Small Modulators of Gene Activation and Repression by Targeting Epigenetic Regulators

The SMARTER Network consists of four research groups with high expertise in chromatin research and Chroma Therapeutics, a company focused on the generation of cancer and inflammation treatments. The SMARTER project aims at the development and improvement of compounds targeting epigenetic regulators. These compounds will be tested in various assays making it possible to collect data sets of several parameters as histone modifications, chromatin states, gene expression patterns and physiological characteristics in an integrative manner. Our network will thereby promote the development and improvement of a new branch of cancer drugs as well as support validation of new potential drug target enzymes. Importantly, research tools will be generated, which allow new insights in fundamental mechanisms of gene regulation by epigenetic modification.